Patients taking SELZENTRY have experienced serious side effects, including liver problems (liver toxicity). An allergic reaction may happen before liver problems occur.

See full Important Safety Information below

Not an actual HIV-1 patient

Understanding HIV-1 and how medicines work.

If you've been living with HIV for a while, chances are you know more than a few things about the condition. It can never hurt to review the basics, though. It may help you if you consider another game plan for treatment.

  • HIV stands for Human Immunodeficiency Virus. It's the virus that causes HIV infection.
  • AIDS means Acquired Immune Deficiency Syndrome. AIDS is the most advanced stage of HIV infection.
  • HIV is transmitted (spread) through the blood, semen, genital fluids, or breast milk of a person infected with HIV. Having unprotected sex or sharing needles and syringes with a person infected with HIV are the most common ways HIV is transmitted.

An infected person can have different amounts of HIV in his or her blood. The amount of HIV in an infected person's blood is called the viral load.

  • Your body has a type of white blood cell called a CD4+ T-cell. CD4+ T-cells help protect you from infection. They are a big part of your immune system. HIV destroys these cells.
  • HIV enters the body's CD4+ T-cells and uses these cells to make copies of itself. This process is called the HIV life cycle. This process of replication also destroys the CD4+ T-cell.
  • When HIV has killed too many CD4+ T-cells, your body can no longer fight off certain infections. These infections are called opportunistic infections.

First, it's important to know that each person's HIV-1 may be different. One way each patient's virus is different is in how it attaches to and makes its way into the CD4+ T-cell.

  • First, HIV-1 attaches to the CD4 receptor on the outside of CD4+ T-cells.
  • Then, HIV-1 attaches to what is called a coreceptor.
  • There are two different coreceptors: CCR5 and CXCR4.
  • Some HIV-1 will use only 1 of these coreceptors, and some can use either.

SELZENTRY helps inhibit the entry of CCR5-tropic HIV-1 into white blood cells called CD4+ T-cells.

SELZENTRY is used with other HIV medicines in adults to treat only CCR5-tropic HIV-1. SELZENTRY is not approved or effective for patients infected with CXCR4-tropic, dual-tropic, or mixed-tropic HIV-1.

  • HIV-1 medicines help stop HIV from using the CD4+ T-cell's machinery to make more copies of the virus. The different HIV-1 medicines do this by interfering with different steps of the HIV life cycle.
  • The use of multiple HIV-1 medicines is called antiretroviral therapy, or ART.
  • ART may reduce the viral load and increase the number of infection-fighting CD4+ T-cells in a person's blood.


What's the connection?

Have more questions about HIV-1 and treatment? Use the list of resources below to continue to take an active role in your treatment.

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SELZENTRY (maraviroc) is a type of prescription medicine that is used to treat only CCR5-tropic HIV-1 in adults.

  • SELZENTRY must be used with other HIV medicines and is not recommended in patients with dual/mixed or CXCR4-tropic HIV-1
  • Your healthcare provider will do a blood test (tropism test) to see if you have been infected with CCR5-tropic HIV-1 before prescribing SELZENTRY for you
  • SELZENTRY does not cure HIV-1 infection or AIDS, and it does not work in all people with CCR5-tropic HIV-1 infection
  • SELZENTRY should not be used in patients younger than 18 years of age
  • It is very important that you stay under the care of your healthcare provider during treatment with SELZENTRY


Patients taking SELZENTRY have experienced serious side effects, including liver problems (liver toxicity). An allergic reaction may happen before liver problems occur. Stop taking SELZENTRY and call your healthcare provider right away if you get any of the following symptoms: an itchy rash on your body (allergic reaction), your skin or eyes look yellow (jaundice), dark (tea-colored) urine, vomiting, or upper right stomach area (abdominal) pain.

Who should not take SELZENTRY: People with severe kidney problems or who are on hemodialysis and are taking certain other medications should not take SELZENTRY. Talk to your healthcare provider before taking this medicine if you have kidney problems.

Before you take SELZENTRY, tell your healthcare provider if you have liver problems including a history of hepatitis B or C, heart problems, kidney problems, low blood pressure or take medicines to lower blood pressure, any other medical condition, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. It is not known if SELZENTRY may harm your unborn baby.

People taking SELZENTRY may still develop infections, including opportunistic infections, or other conditions that happen with HIV-1 infection.

Possible serious side effects of SELZENTRY include:

Do not breastfeed. You should not breastfeed because HIV-1 can be passed to your baby in your breast milk. We do not know whether SELZENTRY can be passed to your baby or whether it could harm your baby.

The long-term effects of SELZENTRY are not known at this time.

Most Common Side Effects

The most common side effects of SELZENTRY include colds, cough, fever, rash, and dizziness. Tell your healthcare provider about any side effect that bothers you or does not go away. These are not all of the side effects with SELZENTRY. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Drug Interactions

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal supplements. Certain other medicines may affect the levels of SELZENTRY in your blood. Your healthcare provider may need to change your dose of SELZENTRY when you take it with certain medicines.

Do not take products that contain St. John's wort (Hypericum perforatum) because it may lower the levels of SELZENTRY in your blood so that it will not work to treat your CCR5-tropic HIV-1 infection.

It is important to take all of your anti-HIV medicines as prescribed and at the same time(s) each day. Do not change your dose or stop taking SELZENTRY or your other anti-HIV medicines without first talking with your healthcare provider. If you take too much SELZENTRY, call your healthcare provider or the poison control center right away. If you forget to take SELZENTRY, take the next dose of SELZENTRY as soon as possible and then take your next scheduled dose at its regular time. If it is less than 6 hours before your next scheduled dose, do not take the missed dose. Instead, wait and take the next dose at the regular time. When your supply of SELZENTRY starts to run low, ask your healthcare provider or pharmacist for a refill.

SELZENTRY comes in 150-mg and 300-mg tablets. Take SELZENTRY 2 times a day. Swallow tablets whole. Do not chew the tablets. You can take SELZENTRY tablets with or without food.